Clinical Trials
Search our team at AdventHealth Research Institute
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NCT06008977
EX-BOOST: Exercise to boost response to checkpoint blockade immunotherapy
This study is currently enrolling.Research Area: Translational ResearchResearch Location: Orlando, FloridaStudy Purpose: To obtain a better understanding on how exercise can improve outcomes for patients with skin cancers.
To be enrolled in this study, you must meet certain requirements. You may be...
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NCT05865535
AV-380-22-102: A Phase 1 Dose Escalation Study of AV-380 in Combination with Standard of Care Chemotherapy in Metastatic Cancer Patients with Cachexia and Elevated GDF-15 Levels
This study is currently enrolling.Research Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe study involves research. The purpose of the study is to see if a single dose and multiple doses of the study drug, AV 380, are safe and tolerated in cancer participants. This study will also help...
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NCT04956640
LOXO-RAS-20001: A Phase 1a/1b Study of LY3537982 in Patients with KRAS G12C-Mutant Advanced Solid Tumors
This study is currently enrolling.Associated Conditions: Multiple Tumor TypesResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe main purpose of this research study (during both monotherapy and combination therapy evaluation) includes the following: To determine whether LY3537982 is safe; To identify which dose level of...
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NCT04427384
A Multicenter Observational Study of GammaTile™ Surgically Targeted Radiation Therapy (STaRT) in Intracranial Brain Neoplasms
This study is currently enrolling.Associated Conditions: Brain CancerResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe purpose of this research is to evaluate real-world clinical outcomes and patient-reported
outcomes that measure the effectiveness and safety of GammaTiles, which is the type of
radiation therapy... -
NCT05346835
68284528MMY4006 EAP: Intermediate-Size Population Expanded Access Program (EAP) for Ciltacabtagene Autoleucel (Cilta-cel) Out-of-Specification (OOS) in Patients With Multiple Myeloma
This study is currently enrolling.Associated Conditions: Multiple MyelomaResearch Area: Clinical Cancer ResearchResearch Location: Orlando, Florida -
NCT05948865
A Phase 1, Multicenter, Single Agent Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Evidence of Antitumor Activity of CPO301, an EGFR-Targeting Antibody-Drug Conjugate, in Adult Patients with Advanced or Metastatic Solid Tumors
This study is currently enrolling.Associated Conditions: Multiple Tumor TypesResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe purpose of the study, called CPO301-US-101, is to see if CPO301 (also known as SYS6010) is safe and effective in treating your type of cancer when administered as an intravenous (administered into...
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NCT05685303
ALLAY-HF: Safety and Efficacy of the Alleviant System for No-Implant Interatrial Shunt Creation in Patients with Chronic Heart Failure
This study is currently enrolling.Research Area: Heart, Lung and Vascular ResearchResearch Location: Orlando, FloridaTo evaluate the safety and efficacy of the Alleviant ALV1 System in
patients with chronic heart failure (HF) and preserved ejection fraction
(HFpEF) or mildly reduced ejection fraction (HFmrEF), who... -
NCT05820087
HOPE4KIDNEY: The HistoSonics Edison System for treatment of primary solid renal tumors using histotripsy (#HOPE4KIDNEY US)
This study is currently enrolling.Research Area: Digestive Health and SurgeryResearch Location: Orlando, FloridaStudy Purpose: The purpose of this trial is to evaluate the effectiveness and safety of the HistoSonics Edison System for the destruction of kidney tissue by treating primary solid renal tumors.
To...
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NCT05822752
M24-147: A Phase 2, Randomized Open-Label Study to Evaluate the Optimized Dose, Safety, and Efficacy of Livmoniplimab in Combination with Budigalimab for locally advanced or Metastatic Hepatocellular Carcinoma (HCC) patients who have progressed after an approved immune checkpoint inhibitor containing regimen in 1L HCC
This study is currently enrolling.Associated Conditions: Liver CancerResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe purpose of this study is to determine the optimal dose of livmoniplimab and to determine if livmoniplimab in combination with budigalimab is safe and effective at treating locally advanced or...
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NCT05198674
The SPYRAL AFFIRM Global Clinical Study of Renal Denervation with the Symplicity Spyral Renal Denervation System in Subjects with Uncontrolled Hypertension (SPYRAL AFFIRM)
This study is currently enrolling.Associated Conditions: Interventional CardiologyResearch Area: Heart, Lung and Vascular ResearchResearch Location: Orlando, FloridaThe purpose of this study is to study renal denervation with the Symplicity Spyral Renal Denervation system in patients with varying severity of uncontrolled high blood pressure and associated...
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NCT04637763
CB-010: A Phase 1, Multicenter, Open-Label Study of CB-010, a CRISPR-Edited Allogeneic Anti-CD19 CAR-T Cell Therapy in Patients with Relapsed/Refractory B Cell Non-Hodgkin Lymphoma (ANTLER)
This study is currently enrolling.Research Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaAllogeneic CAR-T cell therapy is a type of cancer therapy in which a healthy donor’s T cells (a type of immune system cell that circulates in blood) are modified during manufacturing using CRISPR...
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Childhood Sjogren Disease Long Term Outcomes
This study is currently enrolling.Research Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe purpose of this research is to describe the natural history of children diagnosed with, or suspected of being at risk for development of, childhood Sjogren Disease. This is a critically...