Clinical Trials
Search our team at AdventHealth Research Institute
-
NCT04223752
A Phase 1, open-label, non-comparative, multicenter clinical study to evaluate the safety, tolerability, and pharmacokinetics of ceftolozane/tazobactam (MK-7625A) in pediatric participants with nosocomial pneumonia
This study is not currently enrolling.Research Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaCeftolozane/tazobactam, also known as Zerbaxa, is a combination product, and is available by prescription for use in adults for the treatment of complicated urinary tract infections, including...
-
NCT04529772
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Acalabrutinib in Combination with Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R CHOP) in Subjects ≤70 Years with Previously Untreated Non-Germinal Center Diffuse Large B Cell Lymphoma
This study is not currently enrolling.Associated Conditions: LeukemiaResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThis study is being done to understand whether patients with a type of DLBCL known as non-germinal center diffuse large B-cell lymphoma (non-GCB DLBCL) will benefit from the addition of acalabrutinib...
-
Donor Breast Milk and Serum Ferritin Levels in Very Preterm Infants: A Prospective, Observational Study
This study is not currently enrolling.Associated Conditions: NeonatalResearch Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaThe purpose of the study is to compare the iron levels in very preterm infants receiving donor breast milk (DBM) to very preterm infants receiving maternal breast milks (MBM).
-
NCT03000439
You are being asked to take part in this research study because you have Systemic Juvenile Idiopathic Arthritis (sJIA) which may cause joint swelling and pain, fever, or other symptoms affecting the whole body (such as rash, swelling of your lymph nodes, a large liver or spleen, or inflammation of the lining around your lungs or heart). The purpose of this research study is to compare the effectiveness of the study drug, tofacitinib, to placebo for treatment of signs and symptoms of sJIA.
This study is not currently enrolling.Associated Conditions: Immunology/RheumatologistResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaYou are being asked to take part in this research study because you have Systemic Juvenile Idiopathic Arthritis (sJIA) which may cause joint swelling and pain, fever, or other symptoms affecting the...
-
Edited Natural Killer cells as an immunotherapeutic approach for the treatment of pediatric cancers
This study is not currently enrolling.Associated Conditions: Pediatric CancerResearch Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaFreshly resected tumor tissue obtained from neuroblastoma patients will be used to establish in vitro organoid models and characterize the tumor landscape before and after in vitro allogeneic edited...
-
NCT05232929
LONG-TERM FOLLOW-UP STUDY OF PATIENTS WITH SPINAL MUSCULAR ATROPHY RECEIVING RISDIPLAM TREATMENT
This study is not currently enrolling.Associated Conditions: NeurodegenerativeResearch Area: Neuroscience ResearchResearch Location: Orlando, FloridaThe main purpose of this study is to follow patients receiving Evrysdi for a long time. This will add to the body of evidence about the safety and effectiveness of Evrysdi.
-
NCT04471909
TRIOMPHE - A Multi-arm, Multi-Center, Non-Randomized, Prospective, Clinical Study to Evaluate the Safety and Effectiveness of the NEXUS Aortic Arch Stent Graft System in Treating Thoracic Aortic Lesions Involving the Aortic Arch
This study is not currently enrolling.Research Area: Transplant ResearchResearch Location: Orlando, FloridaThis study involves research. The purpose of this research study is to continue to test how well the Endospan NEXUS Aortic Arch Stent Graft System performs in the treatment of a diseased aortic arch...
-
Randomized Trial on Hybrid vs Non-Hybrid ESD for Colorectal Polyps
This study is not currently enrolling.Research Area: Digestive Health and SurgeryResearch Location: Orlando, FloridaWe invite you to take part in a research study because you have colorectal polyp and are being treated here at AdventHealth Orlando. A clinical trial (research study) is done when researchers...
-
NCT04537377
A Phase I/II, Multicenter, Non-randomized, Open Label, Adaptive Design, 5-year Follow up, Single Dose-escalation Study of VTX-801 in Adult Patients with Wilson’s Disease.
This study is not currently enrolling.Associated Conditions: Wilsons DiseaseResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThis Clinical Trial is being conducted to assess the effects of an experimental drug (study drug) called VTX-801 intended to treat Wilson’s Disease (WD). The purpose of this clinical study is to...
-
NCT05064878
A Phase 3, Randomized, Double-blind, Placebo-Controlled, Fixed-Dose, Multicenter Study to Examine the Efficacy and Safety of ZX008 in Subjects with CDKL5 deficiency disorder followed by an Open-Label Extension.
This study is not currently enrolling.Associated Conditions: EpilepsyResearch Area: Neuroscience ResearchResearch Location: Orlando, FloridaThe purpose of this informed consent form is to collect data about the non-paid caregiver of a subject that is participating in ZX008-2103 study. You, as the non-paid caregiver, are being asked to...
-
NCT04945460
A Phase 2, Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effects of Sotatercept versus Placebo for the Treatment of Combined Postcapillary and Precapillary Pulmonary Hypertension (Cpc-PH) due to Heart Failure with Preserved Ejection Fraction (HFpEF)
This study is not currently enrolling.Associated Conditions: Pulmonary HypertensionResearch Area: Heart, Lung and Vascular ResearchResearch Location: Orlando, FloridaYou are being asked to take part in a research study of an experimental treatment called
sotatercept. “Experimental” means that sotatercept is currently being tested and is not
approved for sale by... -
NCT05206773
A Randomized, Double-blind, Placebo-controlled, 12-month Phase 3 Study to Evaluate the Effect of Venglustat on Neuropathic and Abdominal Pain in Male and Female Adults with Fabry Disease who are Treatment-naïve or Untreated for At least 6 Months
This study is not currently enrolling.Research Area: Neuroscience ResearchResearch Location: Orlando, FloridaThe purpose of the study is to evaluate daily oral doses of the study drug called venglustat compared to placebo: what is the effectiveness (how well it works) on symptoms of the Fabry disease, mainly...